exoRBase

exoRBase is an invaluable resource for researchers and scientists in the field of extracellular RNA biology. It serves as a repository that houses a vast collection of messenger RNA (mRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA) data derived from RNA-seq data analyses of human biofluids. Since its inception as exoRBase 1.0 in 2017, it has become an essential tool for liquid biopsy research, particularly in the study of exosomal RNAs from blood. The evolution of exoRBase from version 1.0 to 3.0 has been a significant leap forward. exoRBase 2.0, introduced in 2021, expanded its scope significantly, encompassing 905 exLR-seq datasets across four biofluids, which has allowed for more comprehensive comparative studies. The latest iteration, exoRBase 3.0, represents a transformative update that integrates approximately 3,000 samples. This includes Extracellular Vesicles and Particles (EVPs) and cell-free RNAs (cfRNAs) across a variety of human biofluids. One of the key features of exoRBase 3.0 is the unification of EVP-associated and cell-free long RNAs under the extracellular long RNA (exLR) framework. This integration is crucial for a more holistic understanding of extracellular RNA biology. The database offers researchers the ability to visualize RNA expression profiles, functional pathway-level changes, and the heterogeneity of circulating RNA origins. This comprehensive approach reflects the significant advances in the field and the established utility of extracellular RNA in biomarker discovery for precision medicine. The database is particularly rich in data, with over 19,927 mRNA entries, 15,961 lncRNA entries, and 126,816 circRNA entries. It also provides detailed information on EVPs in biofluids such as blood, urine, cerebrospinal fluid (CSF), and